Prof. Dr. Hermann Josef Girschick

1984 - 1991
Studium der Humanmedizin, Universität Regensburg und Würzburg

1991
Amerikanisches Staatsexamen für Humanmedizin

1991 - 1998
Assistenzarzt, Universitäts-Kinderklinik Würzburg

1997
Facharzt, Kinderheilkunde und Jugendmedizin

1998 - 2000
Research Fellowship an der Universität von Texas, Dallas am Harold C. Simmons Arthritis Research Center

2000 - 2009
Leitung, Funktionsbereich Rheumatologie, Immunologie, Infektiologie, Gastroenterologie und Osteologie, Universitäts-Kinderklinik Würzburg

2002
Habilitation, Universität Würzburg

2005 - 2009
Universitätsprofessur für Kinderheilkunde

seit 2009
Direktor, Klinik für Kinder- und Jugendmedizin im Vivantes Klinikum im Friedrichshain, Berlin

Recombinant Enzyme Replacement Therapy in Hypophosphatasia. Hofmann C, Jakob F, Seefried L, Mentrup B, Graser S, Plotkin H, Girschick HJ, Liese J. Subcell Biochem. 2015;76:323-41. doi: 10.1007/978-94-017-7197-9_15. Review.

Inflammatory Bowel Disease in Juvenile Idiopathic Arthritis Patients Treated with Biologics. Barthel D, Ganser G, Kuester RM, Onken N, Minden K, Girschick HJ, Hospach A, Horneff G. J Rheumatol. 2015 Nov;42(11):2160-5. doi: 10.3899/jrheum.140472. Epub 2015 Sep 15.

Chronic Nonbacterial Osteomyelitis: Pathophysiological Concepts and Current Treatment Strategies. Hofmann SR, Schnabel A, Rösen-Wolff A, Morbach H, Girschick HJ, Hedrich CM. J Rheumatol. 2016 Nov;43(11):1956-1964. Epub 2016 Sep 1. Review.

Altered expression of IL-10 family cytokines in monocytes from CRMO patients result in enhanced IL-1β expression and release. Hofmann SR, Kubasch AS, Ioannidis C, Rösen-Wolff A, Girschick HJ, Morbach H, Hedrich CM. Clin Immunol. 2015 Dec;161(2):300-7. doi: 10.1016/j.clim.2015.09.013. Epub 2015 Sep 25. PMID: 26404542 Similar articles Select item 26667304

No association of IL-12p40 pro1.1 polymorphism with juvenile idiopathic arthritis. Eberhardt CS, Haas JP, Girschick H, Schwarz T, Morbach H, Rösen-Wolff A, Foell D, Dannecker G, Schepp C, Ganser G, Honke N, Eggermann T, Müller-Berghaus J, Wagner N, Ohl K, Tenbrock K. Pediatr Rheumatol Online J. 2015 Dec 15;13:61. doi: 10.1186/s12969-015-0059-z. PMID: 26667304 Free PMC Article Similar articles Select item 25057181

CD226 (DNAM-1) is associated with susceptibility to juvenile idiopathic arthritis. Reinards TH, Albers HM, Brinkman DM, Kamphuis SS, van Rossum MA, Girschick HJ, Wouters C, Hoppenreijs EP, Saurenmann RK, Hinks A, Ellis JA, Bakker E, Verduijn W, Slagboom P, Huizinga TW, Toes RE, Houwing-Duistermaat JJ, ten Cate R, Schilham MW. Ann Rheum Dis. 2015 Dec;74(12):2193-8. doi: 10.1136/annrheumdis-2013-205138. Epub 2014 Jul 23. PMID: 25057181 Similar articles Select item 27000045

Serum biomarkers for the diagnosis and monitoring of chronic recurrent multifocal osteomyelitis (CRMO). Hofmann SR, Kubasch AS, Range U, Laass MW, Morbach H, Girschick HJ, Hedrich CM. Rheumatol Int. 2016 Jun;36(6):769-79. doi: 10.1007/s00296-016-3466-7. Epub 2016 Mar 21. PMID: 27000045 Similar articles Select item 24168981

Prevalence of hepatitis E virus antibodies in children in Germany. Krumbholz A, Neubert A, Joel S, Girschick H, Huppertz HI, Kaiser P, Liese J, Streng A, Niehues T, Peters J, Sauerbrey A, Schroten H, Tenenbaum T, Wirth S, Zell R, Sauerbrei A. Pediatr Infect Dis J. 2014 Mar;33(3):258-62. doi: 10.1097/INF.0000000000000077. PMID: 24168981 Similar articles Select item 23921539

Clinical utility gene card for: hypophosphatasia - update 2013. Mornet E, Hofmann C, Bloch-Zupan A, Girschick H, Le Merrer M. Eur J Hum Genet. 2014 Apr;22(4). doi: 10.1038/ejhg.2013.177. Epub 2013 Aug 7. No abstract available. PMID: 23921539 Free PMC Article Similar articles Select item 24569605

Unexpected high intrafamilial phenotypic variability observed in hypophosphatasia. Hofmann C, Girschick H, Mornet E, Schneider D, Jakob F, Mentrup B. Eur J Hum Genet. 2014 Oct;22(10):1160-4. doi: 10.1038/ejhg.2014.10. Epub 2014 Feb 26. PMID: 24569605 Free PMC Article Similar articles Select item 26346816

Severe immune dysregulation with neurological impairment and minor bone changes in a child with spondyloenchondrodysplasia due to two novel mutations in the ACP5 gene. Girschick H, Wolf C, Morbach H, Hertzberg C, Lee-Kirsch MA. Pediatr Rheumatol Online J. 2015 Sep 7;13(1):37. doi: 10.1186/s12969-015-0035-7. PMID: 26346816 Free PMC Article Similar articles Select item 24524235

Prevalence of antibodies against influenza A and B viruses in children in Germany, 2008 to 2010. Sauerbrei A, Langenhan T, Brandstadt A, Schmidt-Ott R, Krumbholz A, Girschick H, Huppertz H, Kaiser P, Liese J, Streng A, Niehues T, Peters J, Sauerbrey A, Schroten H, Tenenbaum T, Wirth S, Wutzler P. Euro Surveill. 2014 Feb 6;19(5). pii: 20687. PMID: 24524235 Free Article Similar articles Select item 24938481

Psychomotor development following early treatment of severe infantile vitamin B12 deficiency and West syndrome--is everything fine? A case report and review of literature. Glaser K, Girschick HJ, Schropp C, Speer CP. Brain Dev. 2015 Mar;37(3):347-51. doi: 10.1016/j.braindev.2014.05.006. Epub 2014 Jun 14. Review. PMID: 24938481 Similar articles Select item 25065777

A standardized clinical and radiological follow-up of patients with chronic non-bacterial osteomyelitis treated with pamidronate. Hofmann C, Wurm M, Schwarz T, Neubauer H, Beer M, Girschick H, Morbach H. Clin Exp Rheumatol. 2014 Jul-Aug;32(4):604-9. Epub 2014 Jul 23. PMID: 25065777 Similar articles Select item 24347572

Genetic variation in VTCN1 (B7-H4) is associated with course of disease in juvenile idiopathic arthritis. Albers HM, Reinards TH, Brinkman DM, Kamphuis SS, van Rossum MA, Hoppenreijs EP, Girschick HJ, Wouters C, Saurenmann RK, Bakker E, Verduijn W, Slagboom P, Huizinga TW, Toes RE, Houwing-Duistermaat JJ, ten Cate R, Schilham MW. Ann Rheum Dis. 2014 Jun;73(6):1198-201. doi: 10.1136/annrheumdis-2013-204466. Epub 2013 Dec 17. PMID: 24347572 Similar articles Select item 24359092

Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO). Hedrich CM, Hofmann SR, Pablik J, Morbach H, Girschick HJ. Pediatr Rheumatol Online J. 2013 Dec 23;11(1):47. doi: 10.1186/1546-0096-11-47. PMID: 24359092 Free PMC Article Similar articles Select item 27073061

Inflammatory pseudotumor (IPT)-surgical cure of an inflammatory syndrome. Rack A, Belohradsky BH, Grantzow R, Schweinitz DV, Pfluger T, Kammer B, Girschick H, Horst D, Wintergerst U. Eur J Pediatr. 2016 Jul;175(7):903-8. doi: 10.1007/s00431-016-2718-6. Epub 2016 Apr 12. PMID: 27073061 Similar articles Select item 23369460

Autoinflammatory bone disorders. Morbach H, Hedrich CM, Beer M, Girschick HJ. Clin Immunol. 2013 Jun;147(3):185-96. doi: 10.1016/j.clim.2012.12.012. Epub 2013 Jan 5. Review. PMID: 23369460 Similar articles Select item 23812435

Prevalence of antibodies against hepatitis A virus among children and adolescents in Germany. Krumbholz A, Neubert A, Girschick H, Huppertz HI, Kaiser P, Liese J, Streng A, Niehues T, Peters J, Sauerbrey A, Schroten H, Tenenbaum T, Wirth S, Sauerbrei A. Med Microbiol Immunol. 2013 Dec;202(6):417-24. doi: 10.1007/s00430-013-0303-4. Epub 2013 Jun 29. PMID: 23812435 Similar articles Select item 25198363

Chronic non-bacterial osteomyelitis in childhood - a comprehensive review. Morbach H, Girschick HJ. Curr Rheumatol Rev. 2013;9(1):17-21. PMID: 25198363 Similar articles Select item 22377804

An international registry on autoinflammatory diseases: the Eurofever experience. Toplak N, Frenkel J, Ozen S, Lachmann HJ, Woo P, Koné-Paut I, De Benedetti F, Neven B, Hofer M, Dolezalova P, Kümmerle-Deschner J, Touitou I, Hentgen V, Simon A, Girschick H, Rose C, Wouters C, Vesely R, Arostegui J, Stojanov S, Ozgodan H, Martini A, Ruperto N, Gattorno M; Paediatric Rheumatology International Trials Organisation (PRINTO), Eurotraps and Eurofever Projects. Ann Rheum Dis. 2012 Jul;71(7):1177-82. doi: 10.1136/annrheumdis-2011-200549. Epub 2012 Feb 29. PMID: 22377804 Similar articles Select item 23557722

Comorbidity profiles among adult patients with juvenile idiopathic arthritis: results of a biologic register. Raab A, Sengler C, Niewerth M, Klotsche J, Horneff G, Zink A, Girschick H, Weber K, Minden K. Clin Exp Rheumatol. 2013 Sep-Oct;31(5):796-802. Epub 2013 Apr 2. PMID: 23557722 Similar articles Select item 24070048

A clinical and pathomechanistic profile of chronic nonbacterial osteomyelitis/chronic recurrent multifocal osteomyelitis and challenges facing the field. Hedrich CM, Hahn G, Girschick HJ, Morbach H. Expert Rev Clin Immunol. 2013 Sep;9(9):845-54. doi: 10.1586/1744666X.2013.824670. Review. PMID: 24070048 Similar articles Select item 23609932

[B-cell targeted therapy for children and adolescents with rheumatic diseases]. Morbach H, Girschick HJ. Z Rheumatol. 2013 May;72(4):347-53. doi: 10.1007/s00393-012-1064-y. German. PMID: 23609932 Similar articles Select item 20854328

Reference values for B cell subpopulations from infancy to adulthood. Morbach H, Eichhorn EM, Liese JG, Girschick HJ. Clin Exp Immunol. 2010 Nov;162(2):271-9. doi: 10.1111/j.1365-2249.2010.04206.x. Epub 2010 Sep 20. PMID: 20854328 Free PMC Article Similar articles Select item 28708801

Bone and Joint Infections. Saavedra-Lozano J, Falup-Pecurariu O, Faust SN, Girschick H, Hartwig N, Kaplan S, Lorrot M, Mantadakis E, Peltola H, Rojo P, Zaoutis T, LeMair A. Pediatr Infect Dis J. 2017 Aug;36(8):788-799. doi: 10.1097/INF.0000000000001635. No abstract available. PMID: 28708801 Similar articles Select item 21569228

Varicella-zoster virus infections in immunocompromised patients - a single centre 6-years analysis. Wiegering V, Schick J, Beer M, Weissbrich B, Gattenlöhner S, Girschick HJ, Liese J, Schlegel PG, Eyrich M. BMC Pediatr. 2011 May 10;11:31. doi: 10.1186/1471-2431-11-31. PMID: 21569228 Free PMC Article Similar articles Select item 23454488

Compound heterozygosity of two functional null mutations in the ALPL gene associated with deleterious neurological outcome in an infant with hypophosphatasia. Hofmann C, Liese J, Schwarz T, Kunzmann S, Wirbelauer J, Nowak J, Hamann J, Girschick H, Graser S, Dietz K, Zeck S, Jakob F, Mentrup B. Bone. 2013 Jul;55(1):150-7. doi: 10.1016/j.bone.2013.02.017. Epub 2013 Feb 27. PMID: 23454488 Similar articles Select item 21901354

Progress in pediatric rheumatology: apprehend the opportunities of the future without forgetting the lessons from the past. Huppertz HI, Föll D, Girschick H, Minden K, Horneff G. Rheumatol Int. 2011 Oct;31(10):1259-62. doi: 10.1007/s00296-011-2062-0. Epub 2011 Sep 8. No abstract available. PMID: 21901354 Free PMC Article Similar articles Select item 22940633

Attenuated TLR4/MAPK signaling in monocytes from patients with CRMO results in impaired IL-10 expression. Hofmann SR, Morbach H, Schwarz T, Rösen-Wolff A, Girschick HJ, Hedrich CM. Clin Immunol. 2012 Oct;145(1):69-76. doi: 10.1016/j.clim.2012.07.012. Epub 2012 Aug 4. PMID: 22940633 Similar articles Select item 22447885

Long-term outcome of patients with JIA treated with etanercept, results of the biologic register JuMBO. Minden K, Niewerth M, Zink A, Seipelt E, Foeldvari I, Girschick H, Ganser G, Horneff G. Rheumatology (Oxford). 2012 Aug;51(8):1407-15. doi: 10.1093/rheumatology/kes019. Epub 2012 Mar 24. PMID: 22447885 Similar articles Select item 22849717

Diffusion-weighted MRI of bone marrow oedema, soft tissue oedema and synovitis in paediatric patients: feasibility and initial experience. Neubauer H, Evangelista L, Morbach H, Girschick H, Prelog M, Köstler H, Hahn D, Beer M. Pediatr Rheumatol Online J. 2012 Jul 31;10(1):20. doi: 10.1186/1546-0096-10-20. PMID: 22849717 Free PMC Article Similar articles Select item 19629901

[Hypophosphatasia]. Beck C, Morbach H, Stenzel M, Schneider P, Collmann H, Girschick G, Girschick HJ. Klin Padiatr. 2009 Jul-Aug;221(4):219-26. doi: 10.1055/s-0029-1220718. Epub 2009 Jul 23. Review. German. PMID: 19629901 Similar articles Select item 22765947

Comparison of magnetic resonance imaging and 99mTechnetium-labelled methylene diphosphonate bone scintigraphy in the initial assessment of chronic non-bacterial osteomyelitis of childhood and adolescents. Morbach H, Schneider P, Schwarz T, Hofmann C, Raab P, Neubauer H, Düren C, Beer M, Girschick HJ. Clin Exp Rheumatol. 2012 Jul-Aug;30(4):578-82. Epub 2012 Aug 29. PMID: 22765947 Similar articles Select item 20978533

Clinical utility gene card for: hypophosphatasia. Mornet E, Beck C, Bloch-Zupan A, Girschick H, Le Merrer M. Eur J Hum Genet. 2011 Mar;19(3). doi: 10.1038/ejhg.2010.170. Epub 2010 Oct 27. No abstract available. PMID: 20978533 Free PMC Article Similar articles Select item 19713439

Successful treatment of severe or methotrexate-resistant juvenile localized scleroderma with mycophenolate mofetil. Martini G, Ramanan AV, Falcini F, Girschick H, Goldsmith DP, Zulian F. Rheumatology (Oxford). 2009 Nov;48(11):1410-3. doi: 10.1093/rheumatology/kep244. Epub 2009 Aug 27. PMID: 19713439 Similar articles Select item 22076178

B-cell pathology in juvenile idiopathic arthritis. Wiegering V, Girschick HJ, Morbach H. Arthritis. 2010;2010:759868. doi: 10.1155/2010/759868. Epub 2010 Dec 2. PMID: 22076178 Free PMC Article Similar articles Select item 21120559

B cell depletion for autoimmune diseases in paediatric patients. Jansson AF, Sengler C, Kuemmerle-Deschner J, Gruhn B, Kranz AB, Lehmann H, Kleinert D, Pape L, Girschick HJ, Foeldvari I, Haffner D, Haas JP, Moebius D, Foell D, Peitz J, Grote V. Clin Rheumatol. 2011 Jan;30(1):87-97. doi: 10.1007/s10067-010-1630-0. Epub 2010 Dec 1. PMID: 21120559 Similar articles Select item 20722029

Risk factors for severe Muckle-Wells syndrome. Kümmerle-Deschner JB, Tyrrell PN, Reess F, Kötter I, Lohse P, Girschick H, Huemer C, Horneff G, Haas JP, Koitschev A, Deuter C, Benseler SM. Arthritis Rheum. 2010 Dec;62(12):3783-91. doi: 10.1002/art.27696. PMID: 20722029 Free Article Similar articles Select item 21489842

Gastroenteritis in childhood: a retrospective study of 650 hospitalized pediatric patients. Wiegering V, Kaiser J, Tappe D, Weissbrich B, Morbach H, Girschick HJ. Int J Infect Dis. 2011 Jun;15(6):e401-7. doi: 10.1016/j.ijid.2011.02.006. Epub 2011 Apr 12. PMID: 21489842 Free Article Similar articles Select item 22046524

Popliteal cysts in paediatric patients: clinical characteristics and imaging features on ultrasound and MRI. Neubauer H, Morbach H, Schwarz T, Wirth C, Girschick H, Beer M. Arthritis. 2011;2011:751593. doi: 10.1155/2011/751593. Epub 2011 May 5. PMID: 22046524 Free PMC Article Similar articles Select item 22032624

Mutation screening of the IL-1 receptor antagonist gene in chronic non-bacterial osteomyelitis of childhood and adolescence. Beck C, Girschick HJ, Morbach H, Schwarz T, Yimam T, Frenkel J, van Gijn ME. Clin Exp Rheumatol. 2011 Nov-Dec;29(6):1040-3. Epub 2011 Dec 22. PMID: 22032624 Similar articles Select item 20383509

Whole-body MRI in the childhood form of hypophosphatasia. Beck C, Morbach H, Wirth C, Beer M, Girschick HJ. Rheumatol Int. 2011 Oct;31(10):1315-20. doi: 10.1007/s00296-010-1493-3. Epub 2010 Apr 10. PMID: 20383509 Similar articles Select item 21459936

Development of inflammatory bowel disease in patients with juvenile idiopathic arthritis treated with etanercept. van Dijken TD, Vastert SJ, Gerloni VM, Pontikaki I, Linnemann K, Girschick H, Armbrust W, Minden K, Prince FH, Kokke FT, Nieuwenhuis EE, Horneff G, Wulffraat NM. J Rheumatol. 2011 Jul;38(7):1441-6. doi: 10.3899/jrheum.100809. Epub 2011 Apr 1. PMID: 21459936 Similar articles Select item 21792842

Activated memory B cells may function as antigen-presenting cells in the joints of children with juvenile idiopathic arthritis. Morbach H, Wiegering V, Richl P, Schwarz T, Suffa N, Eichhorn EM, Eyrich M, Girschick HJ. Arthritis Rheum. 2011 Nov;63(11):3458-66. doi: 10.1002/art.30569. PMID: 21792842 Free Article Similar articles Select item 20067594

Treatment of Lyme borreliosis. Girschick HJ, Morbach H, Tappe D. Arthritis Res Ther. 2009;11(6):258. doi: 10.1186/ar2853. Epub 2009 Dec 17. Review. PMID: 20067594 Free PMC Article Similar articles Select item 20433730

Chronic nonbacterial osteomyelitis in childhood: prospective follow-up during the first year of anti-inflammatory treatment. Beck C, Morbach H, Beer M, Stenzel M, Tappe D, Gattenlöhner S, Hofmann U, Raab P, Girschick HJ. Arthritis Res Ther. 2010;12(2):R74. doi: 10.1186/ar2992. PMID: 20433730 Free PMC Article Similar articles Select item 21915270

Post-pandemic seroprevalence of pandemic influenza A (H1N1) 2009 infection (swine flu) among children <18 years in Germany. von Kries R, Weiss S, Falkenhorst G, Wirth S, Kaiser P, Huppertz HI, Tenenbaum T, Schroten H, Streng A, Liese J, Shai S, Niehues T, Girschick H, Kuscher E, Sauerbrey A, Peters J, Wirsing von König CH, Rückinger S, Hampl W, Michel D, Mertens T. PLoS One. 2011;6(9):e23955. doi: 10.1371/journal.pone.0023955. Epub 2011 Sep 7. PMID: 21915270 Free PMC Article Similar articles Select item 21284882

Corticosteroid-induced spinal epidural lipomatosis in the pediatric age group: report of a new case and updated analysis of the literature. Möller JC, Cron RQ, Young DW, Girschick HJ, Levy DM, Sherry DD, Kukita A, Saijo K, Pessler F. Pediatr Rheumatol Online J. 2011 Feb 1;9(1):5. doi: 10.1186/1546-0096-9-5. PMID: 21284882 Free PMC Article Similar articles Select item 27777120

A homozygous intronic branch-point deletion in the ALPL gene causes infantile hypophosphatasia. Mentrup B, Girschick H, Jakob F, Hofmann C. Bone. 2017 Jan;94:75-83. doi: 10.1016/j.bone.2016.10.022. Epub 2016 Oct 21.

• Deutsche Gesellschaft für Kinder- und Jugendmedizin (DGKJ)
• Gesellschaft für Kinder und Jugendrheumatologie (GJKR)
• Arbeitsgemeinschaft Pädiatrische Immunologie
• Gesellschaft Pädiatrische Infektiologie
• Paediatric Rheumatology European Society PRES
• Nationale klinische Arbeitgemeinschaften
• Gründungsmitglied der Arbeitsgemeinschaft „nordbayerische und nordbaden-württembergische Zentren für Pädiatrische Rheumatologie“
• Gründungsmitglied des Rheumazentrums Würzburg/Bad Brückenau Gründungsmitglied der Selbsthilfeorganisation Hypophosphatasie e.V.