Prof. Dr. med. Ulrich Böcker, M.A., FEBG

1985 - 1992
Studium der Medizin, Medizinischen Universität zu Lübeck

1987
Aufnahme in die Studienstiftung des Deutschen Volkes

1992
Promotion zum Dr. med.

1992 - 1993
Arzt im Praktikum, Zentrum für Innere Medizin, Universitätsklinikum Essen

1994
Approbation als Arzt

1994 - 1995
Assistenzarzt, II. Medizinische Universitätsklinik (Schwerpunkt Gastroenterologie, Hepatologie und Infektionskrankheiten), Universitätsklinikum Mannheim

1995 - 1997
Stipendiat der Deutschen Forschungsgemeinschaft, Postdoctoral fellow im Department of Medicine an der University of North Carolina at Chapel Hill, U.S.A.

1997 – 2011
Assistenzarzt, ab 2003 Oberarzt, ab 2007 Leitender Oberarzt und Stellvertretender Klinikdirektor der II. Medizinischen Universitätsklinik (Schwerpunkt Gastroenterologie, Hepatologie und Infektionskrankheiten), Universitätsklinikum Mannheim

2001
Erlangung der Bezeichnung Arzt für Innere Medizin

2003
Habilitation mit Erteilung der Venia legendi im Fach Innere Medizin, Fakultät für Klinische Medizin Mannheim, Universität Heidelberg

2004
Erlangung der Schwerpunktbezeichnung Gastroenterologie

2006
Verleihung der Bezeichnung "Außerplanmäßiger Professor" der Universität Heidelberg

2010
Erwerb des akademischen Grads Master of Arts (M.A.) im Studiengang Management von Gesundheits- und Sozialeinrichtungen

2010 – 2011
Stellvertretender Leiter, Zentralen Interdisziplinären Endoskopie, Universitätsmedizin Mannheim

2011
Erwerb der Zusatzbezeichnung Infektiologie

Seit 2011
Chefarzt, Klinik für Innere Medizin IV (Gastroenterologie, Diabetologie und Hepatologie), Vivantes Klinikum Neukölln, Berlin

Leifeld L, Rogler G, Stallmach A, Schmidt C, Zuber-Jerger I, Hartmann F, Plauth M, Drabik A, Hofstädter F, Dienes HP, Kruis W; Detect Dysplasia Study Group. White-Light or Narrow-Band Imaging Colonoscopy in Surveillance of Ulcerative Colitis: A Prospective Multicenter Study. Clin Gastroenterol Hepatol. 2015 Oct;13(10):1776-1781.e1. doi: 10.1016/j.cgh.2015.04.172. Epub 2015 May 5. PubMed PMID: 25952309

Weh J, Antoni C, Weiß C, Findeisen P, Ebert M, Böcker U. Discriminatory potential of C-reactive protein, cytokines, and fecal markers in infectious gastroenteritis in adults. Diagn Microbiol Infect Dis. 2013 Sep;77(1):79-84. doi: 10.1016/j.diagmicrobio.2013.05.005. Epub 2013 Jun 14. PubMed PMID: 23773676

Brühl J, Schirren M, Wei C, Antoni C, Böcker U. Prospective noninvasive analysis of hepatic fibrosis in patients with Crohn's disease: correlation of transient elastography and laboratory-based markers. Eur J Gastroenterol Hepatol. 2011 Oct;23(10):923-30. doi: 10.1097/MEG.0b013e3283499252. PubMed PMID: 21814142

Cornberg M, Protzer U, Petersen J, Wedemeyer H, Berg T, Jilg W, Erhardt A, Wirth S, Sarrazin C, Dollinger MM, Schirmacher P, Dathe K, Kopp IB, Zeuzem S, Gerlich WH, Manns MP; AWMF. [Prophylaxis, diagnosis and therapy of hepatitis B virus infection - the German guideline]. Z Gastroenterol. 2011 Jul;49(7):871-930. doi: 10.1055/s-0031-1273462. Epub 2011 Jul 11. German. PubMed PMID: 21748700

German IBD Study Group. [Adherence to the H1N1 vaccination recommendation in patients with Crohn's disease or ulcerative colitis]. Dtsch Med Wochenschr. 2011 May;136(18):939-43. doi: 10.1055/s-0031-1275829. Epub 2011 May 2. German. PubMed PMID: 21538294

Boll H, Bag S, Nölte IS, Wilhelm T, Kramer M, Groden C, Böcker U, Brockmann MA. Double-contrast micro-CT colonoscopy in live mice. Int J Colorectal Dis. 2011 Jun;26(6):721-7. doi: 10.1007/s00384-011-1181-0. Epub 2011 Mar 25. PubMed PMID: 21437593

Böcker U, Dinter D, Litterer C, Hummel F, Knebel P, Franke A, Weiss C, Singer MV, Löhr JM. Comparison of magnetic resonance imaging and video capsule enteroscopy in diagnosing small-bowel pathology: localization-dependent diagnostic yield. Scand J Gastroenterol. 2010 Apr;45(4):490-500. doi: 10.3109/00365520903567817. PubMed PMID: 20132082

Ehnert S, Knobeloch D, Blankenstein A, Müller A, Böcker U, Gillen S, Friess H, Thasler WE, Dooley S, Nussler AK. Neohepatocytes from alcoholics and controls express hepatocyte markers and display reduced fibrogenic TGF-ß/Smad3 signaling: advantage for cell transplantation? Alcohol Clin Exp Res. 2010 Apr;34(4):708-18. doi: 10.1111/j.1530-0277.2009.01140.x. Epub 2010 Jan 26. PubMed PMID: 20102559

Holtmann MH, Krummenauer F, Claas C, Kremeyer K, Lorenz D, Rainer O, Vogel I, Böcker U, Böhm S, Büning C, Duchmann R, Gerken G, Herfarth H, Lügering N, Kruis W, Reinshagen M, Schmidt J, Stallmach A, Stein J, Sturm A, Galle PR, Hommes DW, D'Haens G, Rutgeerts P, Neurath MF. Significant differences between Crohn's disease and ulcerative colitis regarding the impact of body mass index and initial disease activity on responsiveness to azathioprine: results from a European multicenter study in 1,176 patients. Dig Dis Sci. 2010 Apr;55(4):1066-78. doi: 10.1007/s10620-009-0846-9. Epub 2009 Jun

PubMed PMID: 19513841. 10: Haas SL, Weiss C, Bugert P, Gundt J, Witt H, Singer MV, Berg T, Böcker U. Interleukin 18 promoter variants (-137G>C and -607C>A) in patients with chronic hepatitis C: association with treatment response. J Clin Immunol. 2009 Sep;29(5):620-8. doi: 10.1007/s10875-009-9302-z. Epub 2009 May 20. PubMed PMID: 19455410

Haas SL, Abbatista M, Brade J, Singer MV, Böcker U. Interleukin-18 serum levels in inflammatory bowel diseases: correlation with disease activity and inflammatory markers. Swiss Med Wkly. 2009 Mar 7;139(9-10):140-5. doi: smw-12482. PubMed PMID: 19274491

Böcker U, Löhr JM, Marx A. Twenty-six-year-old female with assumed Crohn's disease and a gastrointestinal stromal tumor: Response. Inflamm Bowel Dis. 2009 Apr;15(4):489-90. doi: 10.1002/ibd.20657. PubMed PMID: 18825771

Franke A, Hummel F, Knebel P, Antoni C, Bocker U, Singer MV, Lohr M. Prospective evaluation of small bowel preparation with bisacodyl and sodium phosphate for capsule endoscopy. World J Gastroenterol. 2008 Apr 7;14(13):2061-4. PubMed PMID: 18395907; PubMed Central PMCID: PMC2701528

Dinter DJ, Chakraborty A, Brade J, Back W, Neff KW, Singer MV, Böcker U. Endoscopy and magnetic resonance imaging in patients with Crohn's disease: a retrospective single-centre comparative study. Scand J Gastroenterol. 2008;43(2):207-16. PubMed PMID: 17918002

Böcker U. Infliximab in ulcerative colitis. Scand J Gastroenterol. 2006 Sep;41(9):997-1000. Review. PubMed PMID: 16938710

Holtmann MH, Krummenauer F, Claas C, Kremeyer K, Lorenz D, Rainer O, Vogel I, Böcker U, Böhm S, Büning C, Duchmann R, Gerken G, Herfarth H, Lügering N, Kruis W, Reinshagen M, Schmidt J, Stallmach A, Stein J, Sturm A, Galle PR, Hommes DW, D'Haens G, Rutgeerts P, Neurath MF. Long-term effectiveness of azathioprine in IBD beyond 4 years: a European multicenter study in 1176 patients. Dig Dis Sci. 2006 Sep;51(9):1516-24. Epub 2006 Aug 22. PubMed PMID: 16927148

Haas SL, Lohse P, Schmitt WH, Hildenbrand R, Karaorman M, Singer MV, Böcker U. Severe TNF receptor-associated periodic syndrome due to 2 TNFRSF1A mutations including a new F60V substitution. Gastroenterology. 2006 Jan;130(1):172-8. PubMed PMID: 16401480

Feick P, Haas SR, Singer MV, Böcker U. Low-dose exposure of intestinal epithelial cells to formaldehyde results in MAP kinase activation and molecular alteration of the focal adhesion protein paxillin. Toxicology. 2006 Feb 15;219(1-3):60-72. Epub 2005 Dec 13. PubMed PMID: 16352387

Haas SL, Andreas Koch W, Schreiber S, Reinhard I, Koyama N, Singer MV, Böcker U. -137 (G/C) IL-18 promoter polymorphism in patients with inflammatory bowel disease. Scand J Gastroenterol. 2005 Dec;40(12):1438-43. PubMed PMID: 16316892

Birrenbach T, Böcker U. Inflammatory bowel disease and smoking: a review of epidemiology, pathophysiology, and therapeutic implications. Inflamm Bowel Dis. 2004 Nov;10(6):848-59. Review. PubMed PMID: 15626903

Mussell M, Böcker U, Nagel N, Singer MV. Predictors of disease-related concerns and other aspects of health-related quality of life in outpatients with inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2004 Nov;16(12):1273-80. PubMed PMID: 15618832

Nebe CT, Rother M, Brechtel I, Costina V, Neumaier M, Zentgraf H, Böcker U, Meyer TF, Szczepek AJ. Detection of Chlamydophila pneumoniae in the bone marrow of two patients with unexplained chronic anaemia. Eur J Haematol. 2005 Jan;74(1):77-83. PubMed PMID: 15613113

Manigold T, Böcker U, Chen J, Gundt J, Traber P, Singer MV, Rossol S. Hepatitis B core antigen is a potent inductor of interleukin-18 in peripheral blood mononuclear cells of healthy controls and patients with hepatitis B infection. J Med Virol. 2003 Sep;71(1):31-40. PubMed PMID: 12858406

Manigold T, Böcker U, Hanck C, Gundt J, Traber P, Antoni C, Rossol S. Differential expression of toll-like receptors 2 and 4 in patients with liver cirrhosis. Eur J Gastroenterol Hepatol. 2003 Mar;15(3):275-82. PubMed PMID: 12610323

Böcker U, Yezerskyy O, Feick P, Manigold T, Panja A, Kalina U, Herweck F, Rossol S, Singer MV. Responsiveness of intestinal epithelial cell lines to lipopolysaccharide is correlated with Toll-like receptor 4 but not Toll-like receptor 2 or CD14 expression. Int J Colorectal Dis. 2003 Jan;18(1):25-32. Epub 2002 Jun 14. PubMed PMID: 12458377

Kalina U, Koyama N, Hosoda T, Nuernberger H, Sato K, Hoelzer D, Herweck F, Manigold T, Singer MV, Rossol S, Böcker U. Enhanced production of IL-18 in butyrate-treated intestinal epithelium by stimulation of the proximal promoter region. Eur J Immunol. 2002 Sep;32(9):2635-43. PubMed PMID: 12207348

Sirenko O, Böcker U, Morris JS, Haskill JS, Watson JM. IL-1 beta transcript stability in monocytes is linked to cytoskeletal reorganization and the availability of mRNA degradation factors. Immunol Cell Biol. 2002 Aug;80(4):328-39. PubMed PMID: 12121221

Böcker U, Sirenko OI, Morris JS, Sartor RB, Singer MV, Haskill JS, Watson JM. Expression and localization of IL-1beta mRNA is interrelated with cytoskeletal rearrangement in monocytes stimulated by adherence: a light microscopy in situ hybridization study. Immunol Cell Biol. 2001 Oct;79(5):444-53. PubMed PMID: 11564152

Böcker U, Schottelius A, Watson JM, Holt L, Licato LL, Brenner DA, Sartor RB, Jobin C. Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells. J Biol Chem. 2000 Apr 21;275(16):12207-13. PubMed PMID: 10766857

Böcker U, Damião A, Holt L, Han DS, Jobin C, Panja A, Mayer L, Sartor RB. Differential expression of interleukin 1 receptor antagonist isoforms in human intestinal epithelial cells. Gastroenterology. 1998 Dec;115(6):1426-38. PubMed PMID: 9834270

Herfarth HH, Böcker U, Janardhanam R, Sartor RB. Subtherapeutic corticosteroids potentiate the ability of interleukin 10 to prevent chronic inflammation in rats. Gastroenterology. 1998 Oct;115(4):856-65. PubMed PMID: 9753488

• American Gastroenterological Association
• Berliner Krebsgesellschaft
• Deutsche Gesellschaft für Innere Medizin
• Deutsche Morbus Crohn Colitis ulcerosa Vereinigung DCCV e. V.
• Deutsche Gesellschaft für Verdauungs- und Stoffwechselkrankheiten
• Deutsche Krebsgesellschaft
• European Association for the Study of the Liver
• European Crohn's and Colitis Organisation
• Gastro-Liga
• Gesellschaft für Gastroenterologie und Hepatologie in Berlin und Brandenburg e.V. Kompetenznetz Darmerkrankungen
• Deutsche Leberstiftung