Prof. Dr. med. Ulrich Adam

1981 - 1987
Studium der Medizin an der Universität Rostock

1987
Beginn der Facharztausbildung „Chirurgie“ an der Chirurgischen Universitätsklinik Rostock (Direktor: Prof. R. Reding bis 1991, Prof. W. Brinckmann 1991 bis 1994)

1989
Promotion Medizinische Fakultät, Universität Rostock

seit 1993
Facharzt für Chirurgie, Fortsetzung der Tätigkeit an der Chirurgischen Universitätsklinik Rostock

1993
Fachkunde „Rettungsmedizin“

seit 1995
Oberarzt an der Abteilung Allgemeine-, Transplantations-, Thorax- und Gefäßchirurgie der Chirurgischen Universitätsklinik Rostock (Direktor: Prof. Dr. Dr. hc. U.T. Hopt)

1998
Fakultative Weiterbildung „Chirurgische Intensivmedizin“

2001
Geschäftsführender Oberarzt der Abteilung Allgemeine- und Visceralchirurgie der Chirurgischen Universitätsklinik Freiburg

2002
Schwerpunktbezeichnung „Visceralchirurgie“

2003
Leitender Oberarzt der Abteilung Allgemeine- und Visceralchirurgie der Chirurgischen Universitätsklinik Freiburg

2005
Habilitation an der Albert-Ludwig-Universität Freiburg im Breisgau

2006
Chefarzt Klinik für Chirurgie / Visceral- und Gefäßchirurgie Vivantes Humboldt Klinikum Berlin

2009
Ernennung zum Apl Professor an der Medizinischen Fakultät der Albert-Ludwig-Universität Freiburg im Breisgau

seit 2012
Ärztlicher Direktor Vivantes Humboldt Klinikum

1.  [Portal vein embolization preparation for major hepatic resection: a new standard in liver surgery]. 
Uhl M, Euringer W, Makowiec F, Adam U, Schneider A, Langer M.
Rofo. 2007 Jan;179(1):31-7. doi: 10.1055/s-2006-927289.
PMID: 17203441 Review. German. 

2.  Bacterobilia in pancreatic surgery-conclusions for perioperative antibiotic prophylaxis. 
Krüger CM, Adam U, Adam T, Kramer A, Heidecke CD, Makowiec F, Riediger H.
World J Gastroenterol. 2019 Nov 7;25(41):6238-6247. doi: 10.3748/wjg.v25.i41.6238.
PMID: 31749594. 

3.  [Does hospital volume have influence on the results of pancreatic surgery?]. 
Keck T, Makowiec F, Adam U, Hopt UT.
Zentralbl Chir. 2007 Feb;132(1):26-31. doi: 10.1055/s-2006-958707.
PMID: 17304432 Review. German. 

4.  Management of delayed visceral arterial bleeding after pancreatic head resection. 
Makowiec F, Riediger H, Euringer W, Uhl M, Hopt UT, Adam U.
J Gastrointest Surg. 2005 Dec;9(9):1293-9. doi: 10.1016/j.gassur.2005.08.003.
PMID: 16332485 Review. 

5.  [S3-Consensus guidelines on definition, etiology, diagnosis and medical, endoscopic and surgical management of chronic pancreatitis German Society of Digestive and Metabolic Diseases (DGVS)]. 
Chronic Pancreatitis German Society of Digestive and Metabolic Diseases (DGVS), Hoffmeister A, Mayerle J, Beglinger C, Büchler MW, Bufler P, Dathe K, Fölsch UR, Friess H, Izbicki J, Kahl S, Klar E, Keller J, Knoefel WT, Layer P, Loehr M, Meier R, Riemann JF, Rünzi M, Schmid RM, Schreyer A, Tribl B, Werner J, Witt H, Mössner J, Lerch MM.
Z Gastroenterol. 2012 Nov;50(11):1176-224. doi: 10.1055/s-0032-1325479. Epub 2012 Nov 13.
PMID: 23150111 German. No abstract available. 

6.  [Surgical therapy of inflammatory and malignant strictures of the common bile duct]. 
Adam U, von Dobschuetz E, Jargon D, Makowiec F, Hopt UT.
Zentralbl Chir. 2004 Dec;129(6):480-6. doi: 10.1055/s-2004-832414.
PMID: 15616912 Review. German. 

7.  Importance of Pancreatic Enzyme Replacement Therapy after Surgery of Cancer of the Esophagus or the Esophagogastric Junction. 
Kiefer T, Krahl D, Osthoff K, Thuss-Patience P, Bunse J, Adam U, Jansen MH, Ott R, Pfitzmann R, Pross M, Kohlmann T, Daeschlein G, Buhlert H, Völler H, Hirt C.
Nutr Cancer. 2018 Jan;70(1):69-72. doi: 10.1080/01635581.2017.1374419. Epub 2017 Sep 25.
PMID: 28945459 

8.  [Leakage after biliary and pancreatic surgery]. 
Hopt UT, Makowiec F, Adam U.
Chirurg. 2004 Nov;75(11):1079-87. doi: 10.1007/s00104-004-0946-1.
PMID: 15448934 German. 

9.  [Impact of Age and Comorbidity on Perioperative Mortality after 250 Pancreatic Head Resections]. 
Riediger H, Krueger CM, Makowiec F, Adam U.
Zentralbl Chir. 2016 Jun;141(3):270-6. doi: 10.1055/s-0041-111520. Epub 2016 Mar 24.
PMID: 27011338 German. 

10.  Prognostic Role of Log Odds of Lymph Nodes After Resection of Pancreatic Head Cancer. 
Riediger H, Kulemann B, Wittel U, Adam U, Sick O, Neeff H, Höppner J, Hopt UT, Makowiec F.
J Gastrointest Surg. 2016 Oct;20(10):1707-15. doi: 10.1007/s11605-016-3200-5. Epub 2016 Jul 6.
PMID: 27384432 

11.  [Steps for solutions and hindrances in progress in relation to an implantable bio-artificial hemofilter-intestine-hybrid kidney]. 
Wüstenberg PW, Dörp E, Schumann L, Adam U, Adam H, Falkenhagen D, Klinkmann H.
Z Urol Nephrol. 1989 Oct;82(10):551-66.
PMID: 2692347 Review. German. 

12.  Randomized controlled single-center trial comparing pancreatogastrostomy versus pancreaticojejunostomy after partial pancreatoduodenectomy. 
Wellner UF, Sick O, Olschewski M, Adam U, Hopt UT, Keck T.
J Gastrointest Surg. 2012 Sep;16(9):1686-95. doi: 10.1007/s11605-012-1940-4. Epub 2012 Jun 29.
PMID: 22744638 Clinical Trial. 

13.  Intraoperative Schnellschnittuntersuchungen parapylorischer Lymphknoten bei der pyloruserhaltenden Pankreaskopfresektion: Gibt es eine klinische Relevanz? 
Riediger H, Schulz A, Adam U, Krüger CM.
Viszeralmedizin. 2014 Feb;30(1):61-4. doi: 10.1159/000358773.
PMID: 26286487 

14.  Risk factors for complications after pancreatic head resection. 
Adam U, Makowiec F, Riediger H, Schareck WD, Benz S, Hopt UT.
Am J Surg. 2004 Feb;187(2):201-8. doi: 10.1016/j.amjsurg.2003.11.004.
PMID: 14769305 

15.  Retrospective analyses of trends in pancreatic surgery: indications, operative techniques, and postoperative outcome of 1,120 pancreatic resections. 
Wittel UA, Makowiec F, Sick O, Seifert GJ, Keck T, Adam U, Hopt UT.
World J Surg Oncol. 2015 Mar 12;13:102. doi: 10.1186/s12957-015-0525-6.
PMID: 25880929 

16.  [Computed Tomography-Based Planimetry of the Pancreatic Transection Line in Risk Evaluation for Postoperative Pancreatic Fistula after Pancreatic Head Resection]. 
Riediger H, Krueger CM, Makowiec F, Adam U, Krüger K.
Zentralbl Chir. 2016 Aug;141(4):446-53. doi: 10.1055/s-0035-1546193. Epub 2015 Aug 10.
PMID: 26258620 German. 

17.  Novel Dynamic Hepatic Magnetic Resonance Imaging Strategy Using Advanced Parallel Acquisition, Rhythmic Breath-Hold Technique, and Gadoxetate Disodium Enhancement. 
Fahlenkamp UL, Wagner M, Nickel D, Adam U, Krueger K, Taupitz M, Schwenke C, Huppertz A.
Invest Radiol. 2016 Jan;51(1):33-40. doi: 10.1097/RLI.0000000000000203.
PMID: 26322554 

18.  Long-term outcome after 92 duodenum-preserving pancreatic head resections for chronic pancreatitis: comparison of Beger and Frey procedures. 
Keck T, Wellner UF, Riediger H, Adam U, Sick O, Hopt UT, Makowiec F.
J Gastrointest Surg. 2010 Mar;14(3):549-56. doi: 10.1007/s11605-009-1119-9. Epub 2009 Dec 22.
PMID: 20033344 

19.  Penetration of moxifloxacin into the human pancreas following a single intravenous or oral dose. 
Wacke R, Förster S, Adam U, Mundkowski RG, Klar E, Hopt UT, Drewelow B.
J Antimicrob Chemother. 2006 Nov;58(5):994-9. doi: 10.1093/jac/dkl353. Epub 2006 Sep 6.
PMID: 16956903 Clinical Trial. 

20.  [Distal pancreatic resection--indications, techniques and complications]. 
Adam U, Makowiec F, Riediger H, Trzeczak S, Benz S, Hopt UT.
Zentralbl Chir. 2001 Nov;126(11):908-12. doi: 10.1055/s-2001-19149.
PMID: 11753802 German. 

21.  Expression of multidrug resistance proteins in rat and human chronic pancreatitis. 
Schaarschmidt T, Merkord J, Adam U, Schroeder E, Kunert-Keil C, Sperker B, Drewelow B, Wacke R.
Pancreas. 2004 Jan;28(1):45-52. doi: 10.1097/00006676-200401000-00007.
PMID: 14707729 

22.  [Symptoms, Diagnostics, Treatment and Classification of 22 Patients with Postpancreatectomy Haemorrhage (PPH) in a Series of 400 Consecutive Pancreatic Head Resections and Pancreatectomies]. 
Riediger H, Krüger K, Makowiec F, Adam U, Krueger CM.
Zentralbl Chir. 2016 Dec;141(6):616-624. doi: 10.1055/s-0042-109978. Epub 2016 Aug 8.
PMID: 27501072 German. 

23.  Postoperative morbidity and long-term survival after pancreaticoduodenectomy with superior mesenterico-portal vein resection. 
Riediger H, Makowiec F, Fischer E, Adam U, Hopt UT.
J Gastrointest Surg. 2006 Sep-Oct;10(8):1106-15. doi: 10.1016/j.gassur.2006.04.002.
PMID: 16966029 

24.  Short- and long-term results of duodenum preservation versus resection for the management of chronic pancreatitis: a prospective, randomized study. 
Keck T, Adam U, Makowiec F, Riediger H, Wellner U, Tittelbach-Helmrich D, Hopt UT.
Surgery. 2012 Sep;152(3 Suppl 1):S95-S102. doi: 10.1016/j.surg.2012.05.016.
PMID: 22906892 Clinical Trial. 

25.  The lymph node ratio is the strongest prognostic factor after resection of pancreatic cancer. 
Riediger H, Keck T, Wellner U, zur Hausen A, Adam U, Hopt UT, Makowiec F.
J Gastrointest Surg. 2009 Jul;13(7):1337-44. doi: 10.1007/s11605-009-0919-2. Epub 2009 May 6.
PMID: 19418101 

26.  A new liposomal formulation of Gemcitabine is active in an orthotopic mouse model of pancreatic cancer accessible to bioluminescence imaging. 
Bornmann C, Graeser R, Esser N, Ziroli V, Jantscheff P, Keck T, Unger C, Hopt UT, Adam U, Schaechtele C, Massing U, von Dobschuetz E.
Cancer Chemother Pharmacol. 2008 Mar;61(3):395-405. doi: 10.1007/s00280-007-0482-z. Epub 2007 Jun 7.
PMID: 17554540 

27.  Pancreatic head resection for chronic pancreatitis in patients with extrahepatic generalized portal hypertension. 
Adam U, Makowiec F, Riediger H, Keck T, Kröger JC, Uhrmeister P, Hopt UT.
Surgery. 2004 Apr;135(4):411-8. doi: 10.1016/j.surg.2003.08.021.
PMID: 15041965 

28.  [Prophylactic splenectomy for splenic vein thrombosis in patients undergoing resection for chronic pancreatitis]. 
Makowiec F, Riediger H, Emmrich J, Kröger J, Hopt UT, Adam U.
Zentralbl Chir. 2004 Jun;129(3):191-5. doi: 10.1055/s-2004-822782.
PMID: 15237324 German. 

29.  Perioperative outcome after pancreatic head resection: a 10-year series of a specialized surgeon in a university hospital and a community hospital. 
Riediger H, Adam U, Utzolino S, Neeff HP, Hopt UT, Makowiec F.
J Gastrointest Surg. 2014 Aug;18(8):1434-40. doi: 10.1007/s11605-014-2555-8. Epub 2014 Jun 5.
PMID: 24898516 

30.  Subcutaneous Redon drains do not reduce the incidence of surgical site infections after laparotomy. A randomized controlled trial on 200 patients. 
Baier PK, Glück NC, Baumgartner U, Adam U, Fischer A, Hopt UT.
Int J Colorectal Dis. 2010 May;25(5):639-43. doi: 10.1007/s00384-010-0884-y. Epub 2010 Feb 6.
PMID: 20140620 Clinical Trial. 

31.  Persistent normoglycemia in the streptozotocin-diabetic rat by syngenic transplantation of islets isolated from a single donor with Liberase. 
Liu X, Günther L, Drognitz O, Neeff H, Adam U, Hopt UT.
Pancreas. 2006 Jan;32(1):9-15. doi: 10.1097/01.mpa.0000191647.40044.58.
PMID: 16340738 

32.  MMP-9 in serum correlates with the development of pulmonary complications in experimental acute pancreatitis. 
Keck T, Jargon D, Klünsch A, Thomusch O, Richter S, Friebe V, Adam U, Hopt UT.
Pancreatology. 2006;6(4):316-22. doi: 10.1159/000092797. Epub 2006 Apr 20.
PMID: 16636607 

33.  Serous cystadenocarcinoma of the pancreas: management of a rare entity. 
Friebe V, Keck T, Mattern D, Schmitt-Graeff A, Werner M, Mikami Y, Adam U, Hopt UT.
Pancreas. 2005 Aug;31(2):182-7. doi: 10.1097/01.mpa.0000167001.89018.3c.
PMID: 16025006 

34.  Long-term outcome after resection for chronic pancreatitis in 224 patients. 
Riediger H, Adam U, Fischer E, Keck T, Pfeffer F, Hopt UT, Makowiec F.
J Gastrointest Surg. 2007 Aug;11(8):949-59; discussion 959-60. doi: 10.1007/s11605-007-0155-6.
PMID: 17534689 

35.  The penetration of ciprofloxacin into human pancreatic and peripancreatic necroses in acute necrotizing pancreatitis. 
Adam U, Herms S, Werner U, Strubelt H, Makowiec F, Hopt UT, Drewelow B.
Infection. 2001 Dec;29(6):326-31. doi: 10.1007/s15010-001-1158-y.
PMID: 11787833 

36.  Expression of connexin26 in islets of Langerhans is associated with impaired glucose tolerance in patients with pancreatic adenocarcinoma. 
Pfeffer F, Koczan D, Adam U, Benz S, von Dobschuetz E, Prall F, Nizze H, Thiesen HJ, Hopt UT, Löbler M.
Pancreas. 2004 Nov;29(4):284-90. doi: 10.1097/00006676-200411000-00007.
PMID: 15502644 

37.  Therapeutic apheresis in myasthenia gravis patients: a six year follow-up. 
Schneidewind JM, Zettl UK, Winkler RE, Ramlow W, Tiess M, Hofmann D, Michelsen A, Weber G, Kinze EM, Adam U, Hauk L, Behnecke R, Klinkmann H.
Ther Apher. 1999 Nov;3(4):298-302. doi: 10.1046/j.1526-0968.1999.00151.x.
PMID: 10608721 Clinical Trial. 

38.  Up-regulation of cytochrome P450 1A2, 2C9, and 2E1 in chronic pancreatitis. 
Wacke R, Kirchner A, Prall F, Nizze H, Schmidt W, Fischer U, Nitschke FP, Adam U, Fritz P, Belloc C, Drewelow B.
Pancreas. 1998 May;16(4):521-8. doi: 10.1097/00006676-199805000-00011.
PMID: 9598815 

39.  Celiac axis stenosis in pancreatic head resection for chronic pancreatitis. 
Pfeiffenberger J, Adam U, Drognitz O, Kröger JC, Makowiec F, Schareck W, Hopt UT.
Langenbecks Arch Surg. 2002 Oct;387(5-6):210-5. doi: 10.1007/s00423-002-0310-1. Epub 2002 Sep 12.
PMID: 12410356 

40.  English language version of the S3-consensus guidelines on chronic pancreatitis: Definition, aetiology, diagnostic examinations, medical, endoscopic and surgical management of chronic pancreatitis. 
Hoffmeister A, Mayerle J, Beglinger C, Büchler MW, Bufler P, Dathe K, Fölsch UR, Friess H, Izbicki J, Kahl S, Klar E, Keller J, Knoefel WT, Layer P, Loehr M, Meier R, Riemann JF, Rünzi M, Schmid RM, Schreyer A, Tribl B, Werner J, Witt H, Mössner J, Lerch MM; members of the guideline committee.
Z Gastroenterol. 2015 Dec;53(12):1447-95. doi: 10.1055/s-0041-107379. Epub 2015 Dec 14.
PMID: 26666283 

41.  Expression and function of beta-glucuronidase in pancreatic cancer: potential role in drug targeting. 
Sperker B, Werner U, Mürdter TE, Tekkaya C, Fritz P, Wacke R, Adam U, Gerken M, Drewelow B, Kroemer HK.
Naunyn Schmiedebergs Arch Pharmacol. 2000 Aug;362(2):110-5. doi: 10.1007/s002100000260.
PMID: 10961372 

42.  Impairment of pancreatic microcirculation in the early reperfusion period during simultaneous pancreas-kidney transplantation. 
Benz S, Pfeffer F, Adam U, Schareck W, Hopt UT.
Transpl Int. 1998;11 Suppl 1:S433-5. doi: 10.1007/s001470050515.
PMID: 9665033 

43.  p53 and K-ras mutations in pancreatic juice samples from patients with chronic pancreatitis. 
Löhr M, Müller P, Mora J, Brinkmann B, Ostwald C, Farré A, Lluis F, Adam U, Stubbe J, Plath F, Nizze H, Hopt UT, Barten M, Capellá G, Liebe S.
Gastrointest Endosc. 2001 Jun;53(7):734-43. doi: 10.1067/mge.2001.112711.
PMID: 11375580 

44.  Delayed gastric emptying after pylorus-preserving pancreatoduodenectomy is strongly related to other postoperative complications. 
Riediger H, Makowiec F, Schareck WD, Hopt UT, Adam U.
J Gastrointest Surg. 2003 Sep-Oct;7(6):758-65. doi: 10.1016/s1091-255x(03)00109-4.
PMID: 13129553 

45.  [Therapeutic splitting as standard treatment for cholelithiasis]. 
Hopt UT, Adam U.
Chirurg. 2006 Apr;77(4):307-14. doi: 10.1007/s00104-006-1178-3.
PMID: 16568257 German. 

46.  Giant ancient schwannoma of pancreatic head treated by extended pancreatoduodenectomy. 
von Dobschuetz E, Walch A, Werner M, Hopt UT, Adam U.
Pancreatology. 2004;4(6):505-8. doi: 10.1159/000080247. Epub 2004 Aug 16.
PMID: 15316226 

47.  Prediction of in vivo drug interaction from in vitro systems exemplified by interaction between verapamil and cimetidine using human liver microsomes and primary hepatocytes. 
Fischer U, Rohde B, Wacke R, Stange J, Nitschke FP, Adam U, Drewelow B.
J Clin Pharmacol. 1997 Dec;37(12):1150-9. doi: 10.1002/j.1552-4604.1997.tb04300.x.
PMID: 9506011 

48.  Islet autotransplantation combined with pancreatectomy for treatment of pancreatic adenocarcinoma: a case report. 
Förster S, Liu X, Adam U, Schareck WD, Hopt UT.
Transplant Proc. 2004 May;36(4):1125-6. doi: 10.1016/j.transproceed.2004.04.048.
PMID: 15194392 

49.  [Pancreatic leakage after pancreas resection. An analysis of 345 operated patients]. 
Adam U, Makowiec F, Riediger H, Benz S, Liebe S, Hopt UT.
Chirurg. 2002 May;73(5):466-73. doi: 10.1007/s00104-002-0427-3.
PMID: 12089831 German. 

50.  Heterotopic pancreatitis with obstruction of the major duodenal papill--a rare trigger of obstructive orthotopic pancreatitis. 
Obermaier R, Walch A, Kurtz C, von Dobschuetz E, Adam U, Neeff H, Benz S, Hopt UT.
Pancreatology. 2004;4(3-4):244-8. doi: 10.1159/000078435. Epub 2004 May 12.
PMID: 15148443 

51.  Islet autotransplantation combined with total pancreatectomy for treatment of pancreatic adenocarcinoma. 
Liu X, Förster S, Adam U, Schmidt W, Müller P, Hopt UT.
Transplant Proc. 2001 Feb-Mar;33(1-2):662-3. doi: 10.1016/s0041-1345(00)02190-4.
PMID: 11267005 No abstract available. 

52.  [Programmed lavage as a basic principle in therapy of diffuse peritonitis]. 
Adam U, Ledwon D, Hopt UT.
Langenbecks Arch Chir. 1997;382(4 Suppl 1):S18-21. doi: 10.1007/pl00014638.
PMID: 9333702 German. 

53.  [Thyroid surgeons thus protect the patients from vocal cord paralysis]. 
Thomusch O, Adam U.
MMW Fortschr Med. 2004 Nov 18;146(47):80.
PMID: 15624668 German. No abstract available. 

54.  [Primary aortoduodenal fistula as a late complication of para-aortic radiation therapy. A case report]. 
Drognitz O, Pfeiffenberger J, Schareck W, Adam U, Nizze H, Hopt UT.
Chirurg. 2002 Jun;73(6):633-7. doi: 10.1007/s00104-001-0415-z.
PMID: 12149951 German. 

55.  [Successful catheter-guided local thrombolysis in acute pulmonary embolism in the early postoperative period after pancreatic head resection]. 
Obermaier R, Kröger JC, Benz S, Makowiec F, Schareck W, Adam U, Hopt UT.
Chirurg. 2002 Sep;73(9):945-9. doi: 10.1007/s00104-002-0499-0.
PMID: 12297963 German. 

56.  [Incentive for rethinking--early enteral nutrition in patients with pancreatitis]. 
Rünzi M, Schneider A, Löhr M, Adam U, Liebe S.
Z Gastroenterol. 1999 Apr;37(4):317-20.
PMID: 10378369 Clinical Trial. German. No abstract available. 

57.  Complete pancreatic encasement of the portal vein--surgical implications of an extremely rare anomaly. 
Marjanovic G, Obermaier R, Benz S, Bley T, Juettner E, Hopt UT, Adam U.
Langenbecks Arch Surg. 2007 Jul;392(4):489-91. doi: 10.1007/s00423-006-0123-8. Epub 2007 Jan 13.
PMID: 17221270 

58.  Rapid HPLC assay for verapamil and its metabolites: use for application to in vitro studies. 
Fischer U, Wacke R, Stange J, Nitschke FP, Adam U, Drewelow B.
Pharmazie. 1996 Apr;51(4):220-3.
PMID: 8628739 

59.  [The selective elimination function of the colon in a rat model for the substances water and urea in long-term experiments as a contribution to the development of an implantable hemofilter-intestine-hybrid kidney]. 
Schröder J, Schumann L, Wüstenberg PW, Dörp E, Adam U, Falkenhagen D, Klinkmann H.
Z Exp Chir Transplant Kunstliche Organe. 1988;21(3):133-8.
PMID: 3407253 German. 

60.  [A new method for pseudocysto-duodenostomy as therapy in pancreatic pseudocyst in chronic pancreatitis]. 
Vankemmel M, Bertaux D, Vandenbossche P, Landen S, Vankemmel FM, Adam U.
Zentralbl Chir. 1990;115(18):1155-9.
PMID: 2244421 German. 

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